Vitamin D, Chronic Migraine, and Extracranial Pain: Is There a Link? Data From an Observational Study

Several studies focused on the role of vitamin D (vitD) in pain chronification. This study vitD level and chronification extension headache disorders. Eighty patients with primary underwent neurological examination, laboratory exams, including serum calcifediol 25(OH)D, features assessment along three questionnaires investigating depression, anxiety, allodynia. The 86.8% population had migraine (48% episodic 52% chronic). 44.1% extracranial pain, 47.6% suffered from A deficit, namely a 25(OH)D <20 ng/ml, was detectable 46.1% patients, it occurred more frequently ( p = 0.009) suffering chronic (CM)–medication overuse (MOH) (62.9%) than (EM, 25.7%) or tension-type (TTH, 11.4%). occurrence allodynia higher CM-MOH EM TTH groups but not related to co-occurrence deficiency (Fisher's exact test 0.11 0.32, respectively). Our findings show that deficit is also headache, probably because anti-inflammatory tolerogenic properties, reinforcing idea neuroinflammatory mechanism underpinning